InVivoSIM anti-human IL-23 (p19) (Guselkumab Biosimilar)
Catalog #SIM0025
Clone:
Guselkumab
Reactivities:
Human
Product Details
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Guselkumab making it ideal for research use. This Guselkumab biosimilar reacts with the p19 subunit of human IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNĪ³ production by memory T cells. Additionally, IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. Guselkumab targets the IL-23 p19 subunit preventing it from binding to cell receptors that would otherwise be activated by its presence. Guselkumab is used to treat moderate to severe plaque psoriasis, and psoriatic arthritis.Specifications
| Isotype | Human IgG1, Ī» |
|---|---|
| Recommended Isotype Control(s) | RecombiMAb human IgG1 isotype control, anti-respiratory syncytial virus |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Immunogen | Human IL-23 p19 |
| Reported Applications |
IL-23p19 neutralization Functional assays ELISA Western blot |
| Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin |
<1EU/mg (<0.001EU/Ī¼g) Determined by LAL gel clotting assay |
| Sterility | 0.2 Āµm filtration |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
Recommended Products
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Recommended Isotype Control(s)
RecombiMAb human IgG1 isotype control, anti-respiratory syncytial virus
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
