Cell Depletion Antibodies

Cell depletion antibodies are reported for use within in vivo studies where the injected depletion antibody is intended to deplete a specific cell type. These experiments are useful to extend and confirm results obtained with genetic knock-out mouse strains or to provide information about the direct biological relevance of a certain cell type.

These antibodies mediate cell depletion through multiple mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent cellular phagocytosis (ADCP). For information about the dosage and kinetics of administration for the in vivo injection of these antibodies, we have compiled an up-to-date list of references for each depletion antibody. These can be found on the individual product pages. We encourage you to review these papers and others in the literature to find the optimal protocol for your experimental system and goals.