InVivoMAb anti-mouse IL-6R
Product Details
The 15A7 monoclonal antibody reacts with the mouse IL-6 receptor Ī± chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. CD126 is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor Ī± chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. The 15A7 monoclonal antibody has been shown to block the binding of IL-6 to the IL-6 receptor.Specifications
Isotype | Rat IgG2b, Īŗ |
---|---|
Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin |
Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
Immunogen | OKT-4 hybridoma cells |
Reported Applications |
in vivo blocking of IL-6/IL-6R signaling in vitro blocking of IL-6R signaling |
Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
Endotoxin |
<2EU/mg (<0.002EU/Ī¼g) Determined by LAL gel clotting assay |
Sterility | 0.2 Ī¼M filtered |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein A High Salt |
RRID | AB_1107588 |
Molecular Weight | 150 kDa |
Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |
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