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RecombiMAb anti-mouse CSF1R (CD115)

Catalog #CP131
Clone:
AFS98-CP131
Reactivities:
Mouse

$217.00 - $5,910.00

$217.00 - $5,910.00

Choose an Option...
  • 100 mg - $5,910.00
  • 50 mg - $4,229.00
  • 25 mg - $2,942.00
  • 5 mg - $843.00
  • 1 mg - $217.00
  • Custom Amount (Quotes Only)
In stock
Only %1 left
Often Bundled With:
Isotype:
Mouse IgG2a
(switched from rat IgG2a)
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Technical Data SheetSafety Data SheetCoA

Product Details

The AFS98-CP131 monoclonal antibody is a chimeric version of the original AFS98 antibody. The variable domain sequences are identical to the original AFS98 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The AFS98-CP131 antibody contains no Fc mutations just as the original rat IgG2a antibody does not. The AFS98-CP131 monoclonal antibody reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. In mice CSF1R is expressed by monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. CSF1R is a receptor for CSF1 and CSF1 signaling through CSF1R regulates the proliferation and differentiation of cells in the monocytic lineage. The AFS98 antibody has been reported to deplete macrophages and block CSFR1 in vivo.

Specifications

Isotype Mouse IgG2a, Īŗ
Recommended Isotype Control(s) InVivoPlus mouse IgG2a isotype control, unknown specificity
Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen Not available or unknown
Reported Applications in vivo macrophage depletion*
in vitro CSF1R neutralization*
in vivo monocyte depletion*
Flow cytometry*
Western blot*
*Reported for the original rat IgG2a AFS98 antibody
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <1EU/mg (<0.001EU/Ī¼g)
Determined by LAL gel clotting assay
Sterility 0.2 Āµm filtration
Production Purified from CHO cell supernatant in an animal free facility
Purification Protein A
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze.

Additional Formats

Recommended Products

Related Products

  1. InVivoMAb anti-human CSF1R (CD115) (clone 2-4A5-4)
  2. InVivoPlus anti-mouse CSF1R (CD115) (clone AFS98)
  3. InVivoMAb anti-mouse CSF1R (CD115) (clone AFS98)