RecombiMAb anti-mouse CD71 (TfR1)
Catalog #CP130
Clone:
R17 217.1.3-CP130
Reactivities:
Mouse
Isotype:
Mouse IgG2a
(switched from rat IgG2a)
(switched from rat IgG2a)
Product Details
The R17 217.1.3-CP130 monoclonal antibody is a chimeric version of the original R17 217.1.3 antibody. The variable domain sequences are identical to the original R17 217.1.3 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The R17 217.1.3-CP130 antibody contains no Fc mutations just as the original rat IgG2a antibody does not. The R17 217.1.3-CP130 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. Due to its important role in proliferation and cellular iron intake as well as the fact that many cancerous cells express high levels of CD71 it is being explored as a potential new target in cases of human leukemia & lymphoma. The R17 217.1.3 antibody has been shown to deplete CD71+ erythroid splenocytes.Specifications
Isotype | Mouse IgG2a, Īŗ |
---|---|
Recommended Isotype Control(s) | InVivoPlus mouse IgG2a isotype control, unknown specificity |
Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
Immunogen | Mouse erythroleukemia cell line 745.6 |
Reported Applications |
in vivo depletion of CD71+ cells* *Reported for the original rat IgG2a R17 217.1.3 antibody |
Formulation |
PBS, pH 7.0 Contains no stabilizers or preservatives |
Endotoxin |
<1EU/mg (<0.001EU/Ī¼g) Determined by LAL gel clotting assay |
Sterility | 0.2 Āµm filtration |
Production | Purified from CHO cell supernatant in an animal free facility |
Purification | Protein G |
Molecular Weight | 150 kDa |
Storage | The antibody solution should be stored at the stock concentration at 4Ā°C. Do not freeze. |